蔡乐

蔡乐（博士，教授，硕士生导师）

专业：分析化学

团队：分离分析团队

电话：0871-65033719

电子信箱：caile@ynu.edu.cn

受教育经历及工作经历：

2000、2003和2006年先后获华西医科大学理学学士、四川大学理学硕士和博士学位；

2007年，云南大学化学科学与工程学院·药学院工作；

2016年，评为教授，并担任云南大学化学科学与工程学院•药学院副院长。

教学：

主讲《药用植物与生药学》和《物质结构鉴定与表征》。

研究领域和兴趣：

微生物发酵改性中药材，微生物转化反应以及天然药物化学研究。

论文、专著：

学术论文

[1] Wang Jiapeng, Yu Jing, Shu Yan, Shi Yaxian, Luo Ping, Cai Le*, Ding Zhongtao*. Peniroquesines A−C: Sesterterpenoids Possessing a 5−6−5−6−5-Fused Pentacyclic Ring System from Penicillium roqueforti YJ-14. Organic Letters, 20(18): 5853-5856, 2018

[2] Dong Jianwei, Cai Le, Li Xuejiao, Duan Rongting, Shu Yan, Chen Fengyun, Wang Jiapeng; Zhou Hao, Ding Zhongtao*. Production of a new tetracyclic triterpene sulfate metabolite sambacide by solid-state cultivated Fusarium sambucinum B10.2 using potato as substrate. Bioresource Technology, 218: 1266-1270, 2016 (并列第一)

[3] Xing Yun, Cai Le*, Yin Tianpeng, Chen Yang, Yu Jing, Wang Yarong, Ding Zhongtao*. Improving the antioxidant activity and enriching salvianolic acids by the fermentation of Salvia miltiorrhizae with Geomyces luteus. Journal of Zhejiang University. Science. B, 17: 391-398, 2016

[4] Cai Le, Dong Jianwei, Zhao Lixing, Zhou Hao, Xing Yun, Li Ying, Li Zhenjie, Duan Weihe, Li Xuejiao, Ding Zhongtao*. An improved water-soluble/stereospecific biotransformation of aporphine alkaloids in Stephania epigaea to 4R-hydroxyaporphine alkaloids by Clonostachys rogersoniana. Process Biochemistry, 91: 933-940, 2016

[5] Yang Minghui, Fang Yunshan, Cai Le*, Li Ying, Dong Jianwei, Yin Tianpeng, Huang Caili, Ding Zhongtao. A new flavone C-glycoside and a new bibenzyl from Bulbophyllum retusiusculum. Natural product research, 30: 1617-1622, 2016 

[6] Dong Jianwei, Cai Le*, Fang Yunshan, Duan Weihe. Li Zhenjie, Ding Zhongtao*. Simultaneous, Simple and Rapid Determination of Five Bioactive Free Anthraquinones in Radix et Rhizoma Rhei by Quantitative 1H NMR. Journal of the Brazilian Chemical Society, 27: 2120-2126, 2016

[7] 马迎聪, 俞静, 王家鹏, 蔡乐*, 丁中涛. 韭菜根的化学成分研究. 中国药学杂志, 51: 972-975, 2016

[8] Li Xuejiao, Cai Le*, Mei Ruifeng, Ding Zhongtao. Improving the acetylcholinesterase inhibitory effect of Illigera henryi by solid-state fermentation with Clonostachys rogersoniana. Journal of Bioscience and Bioengineering, 124(5): 493-497, 2017

[9] Yin Tianpen, Shu Yan, Zhou Hao, Cai Le*, Ding Zhongtao*.Nagarines A and B, two novel 8,15-seco diterpenoid alkaloids from Aconitum nagarum. Fitoterapia, 135: 1-4, 2019

[10] Dong Jianwei, Cai Le*, Li Xuejiao, Wang Jiapeng, Mei Ruifeng, Ding Zhongtao*. Monoterpene esters and aporphine alkaloids from Illigera aromatica with inhibitory effects against cholinesterase and NO production in LPS-stimulated RAW264.7 macrophages. Archives of pharmacal research, 40(12): 1394-1402, 2017

[11] Dong Jianwei, Cai Le, Li Xue Jiao, Peng Li, Xing Yun, Mei Ruifeng, Wang Jiapeng, Ding Zhongtao*. Two new peroxy fatty acids with antibacterial activity from Ophioglossum thermale Kom. Fitoterapia, 109: 212-216, 2016 (共同第一)

[12] 韦琨, 蔡乐*, 刘金, 周皓, 曹秋娥. 我校新开教学实验“荷包牡丹碱的分离纯化”的设计. 中国医药导报, 13(2): 167-169, 2016

[13] Yin Tianpeng, Cai Le, Xing Yun, Yu Jing, Li Xuejiao, Mei Ruifeng, Ding Zhongtao*.  Alkaloids with antioxidant activities from aconitum handelianum. Journal of Asian Natural Products Research, 18: 603-610, 2016 (共同第一)

[14] 尹田鹏, 俞静, 王家鹏, 蔡乐*, 丁中涛. 黄草乌根部内生真菌的分离与鉴定. 中国医药导报, 13(30): 9-11, 2016

[15] Dong Jianwei, Cai Le*, Li Xuejiao, Mei Ruifeng, Wang Jiapeng, Luo ping, Shu Yan, Ding Zhongtao*. Fermentation of Illigera aromatica with Clonostachys rogersoniana producing novel cytotoxic menthane-type monoterpenoid dimers. RSC Advances, 7: 38956-38964, 2017

[16] Fang Yunshan, Liu Shixi, Ma Yingcong, Dong Jianwei, Cai Le*, Ding Zhongtao. A new phenylpropanoid glucoside and a chain compound from the roots of Allium tuberosum. Natural product research, 31: 70-76, 2017

[17] Li Xuejiao, Dong Jianwei, Cai Le*, Wang Jiapeng, Yu Nenxiang, Ding Zhongtao*. Illigerones A and B, two new long-chain secobutanolides from Illigera henryi W. W. Sm. Phytochemistry Letters, 19: 181-186, 2017

[18] Wang Jiapeng, Cai Le, Chen Fengyun, Li Yuanyuan, Li Yuanya, Luo Ping, Ding Zhongtao*. A new steroid with unique rearranged seven-membered B ring isolated from roots of Asparagus filicinus. Tetrahedron Letters, 58(37): 3590-3593, 2017 (共同第一)

[19] Yin Tianpeng, Xing Yun, Cai Le*, Yu Jing, Luo Ping, Ding Zhongtao*. A new polyketide glycoside from the rhizospheric Clonostachys rogersoniana associated with Panax notoginseng. Journal of Asian Natural Products Research, 19(12): 1258-1263, 2017

[20] Yu Jing, Yin Tianpeng, Wang Jiapeng, Mei Ruifeng, Cai Le*, Ding Zhongtao*. A new C20-diterpenoid alkaloid from the lateral roots of Aconitum carmichaeli. Natural product research, 31: 228–232, 2017

[21] Dong Jianwei, Cai Le*, Li Xuejiao, Shu Yan, Wang Jiapeng, Ding Zhongtao*. A novel sesquiterpene derivative with a seven-membered B ring from Illigera aromatic. Natural Product Research, 32: 2589-2595, 2018

[22] Dong Jianwei, Cai Le*, Li Xuejiao, Mei Ruifeng, Luo Ping; Ding Zhongtao*. Improving antioxidant activity of Ophioglossum thermale Kom. by fermentation with Talaromyces purpurogenus M18-11. Journal of the Brazilian Chemical Society, 29: 1927-1933, 2018 

[23] Fang Yunshan, Yang Minghui, Cai Le*, Wang Jiapeng, Yin Tianpeng, Yu Jing, Ding Zhongtao*. New phenylpropanoids from Bulbophyllum retusiusculum. Archives of Pharmacal Research, 41: 1074-1081, 2018 

[24] Shu Yan, Yin Tianpeng, Wang Jiapeng, Gan Dong, Zhang Qinyan, Cai Le*, Ding Zhongtao*. Three new diterpenoid alkaloids isolated from Aconitum brevicalcaratum. Chinese Journal of Natural Medicines, 16: 866-870, 2018

[25] Yin Tianpeng, Shu Yan, Mei Ruifeng, Wang Jiapeng, Cai Le*, Ding Zhongtao*. Diterpenoid alkaloids from Aconitum taronense and their chemotaxonomic significance. Biochemical Systematics and Ecology, 81: 99-101, 2018

[26] Yin Tianpeng, Hu Xiaofang, Mei Ruifeng, Shu Yan, Gan Dong, Cai Le*, Ding Zhongtao*. Four new diterpenoid alkaloids with anti-inflammatory activities from Aconitum taronense Fletcher et Lauener. Phytochemistry Letters, 25: 152-155, 2018

专著及教材

[1] 蔡乐主编，高等学校化学实验室安全基础，化学工业出版社，2018年，北京。

科研项目、成果和专利：

1．苏铁蕨活性成分研究以及brainicine B 及其异构体的合成研究，国家自然科学基金（21002084，青年基金），2011.01-2013.12。（主持）

2．四种滇产乌头的发酵改性及发酵乌头的镇痛抗炎活性物质基础研究，国家自然科学基金（81460648，地区基金），2015.01-2018.12。（主持）

3．Clonostachys rogersoniana发酵改性香青藤的化学机制及抗肿瘤活性物质基础研究，国家自然科学基金（81660719，地区基金），2017.01-2020.12。（主持）

4．尖孢镰刀菌对滇产土牛膝的发酵改性研究，国家自然科学基金（81960760，地区基金），2020.01-2023.12。（主持）

5．棠梨花和短瓣兰的抗肿瘤和抗氧化活性成分研究，云南省自然科学基金（2010CD017，面上项目），2011.01-2013.12。（主持）

6．云南省中青年学术和技术带头人后备人才，云南省科技厅（2018HB036），2018.01-2022.12。

7．丁中涛，蔡乐，李莹．“通过尖孢镰刀菌发酵改性小百部富集红苋甾酮的新方法”，中国发明专利，专利号：ZL201510284205.1。

8．丁中涛，蔡乐，董建伟．“一种通过固体发酵镰孢菌Fusarium sp.产生新抗菌剂sambacide的方法”，中国发明专利，专利号：ZL201610421717.2。

9．蔡乐，罗伟，丁中涛，董建伟．“通过罗杰斯无性穗霉发酵处理香青藤制备化合物的方法及应用”，专利号：201710603948.X。

奖励、荣誉和学术兼职：

云南省高等学校药学类（含临床药学、制药工程等）专业教学指导委员会副主任委员。